Elacridar hydrochloride

Cat. No. 4646

Elacridar hydrochloride C34H33N3O5.HCl [143851-98-3]

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Alternative Name: GF 120918

Chemical Name: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

Biological Activity

P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
600.1
Formula:
C34H33N3O5.HCl
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
143851-98-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Myer et al (1999) The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Oncol Rep. 6 217. PMID: 9864431.

Hyafil et al (1993) In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res. 53 4595. PMID: 8402633.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Elacridar hydrochloride include:

Jablonski et al (2014) Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Ann Clin Transl Neurol 1 996. PMID: 25574474.

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View Related Products by Product Action

Keywords: Elacridar hydrochloride, supplier, GF120918, P-glycoprotein, P-gp, inhibitors, multidrug, resistance, MDR, BCRP, ABCG1, ABCG2, ABCB1, Tocris Bioscience, Multidrug Transporter Inhibitor products

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