Cat. No. 4643
Chemical Name: N-Hydroxy-1-[(4-methoxyphenyl)methy
Biological ActivityPotent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Pipalia et al (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 108 5620. PMID: 21436030.
Balasubramanian et al (2008) A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22 1026. PMID: 18256683.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PCI 34051 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PCI 34051, supplier, PCI34051, potent, selective, histone, deacetylase, 8, (HDAC8), inhibitors, inhibits, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
HDAC5 and HDAC9 inhibitorMC 1742
Potent class I and IIb HDAC inhibitorYK 3-237
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.