TT 232

Cat. No. 4639

TT 232 D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2 (Disulfide bridges: 2 - 6)

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Biological Activity

Peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.

Technical Data


(Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313. PMID: 17961545.

Tejeda et al (2006) Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 26 3477. PMID: 17094470.

Kéri et al (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 93 12513. PMID: 8901613.

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Keywords: TT 232, supplier, TT232, sst4, sst1, somatostatin, receptors, analogue, inhibits, tyrosine, kinase, antitumor, antiproliferative, apoptosis, Tocris Bioscience, Somatostatin (sst) Receptor Agonist products

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