Cat. No. 4637
Biological ActivityToll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542. PMID: 21991317.
Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030. PMID: 17308304.
Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616. PMID: 16129684.
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Keywords: Pam2CSK4, supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Tocris Bioscience, Toll-like Receptor Agonist products
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