Pam2CSK4

Cat. No. 4637

Pam2CSK4 Pam2-Cys-Ser-Lys-Lys-Lys-Lys

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Biological Activity

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Technical Data

M.Wt:
1271.83
Formula:
C65H126N10O12S
Sequence:
CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Solubility:
Soluble to 1 mg/ml in 0.25% acetic acid
Storage:
Store at -20°C
CAS No:
868247-72-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542. PMID: 21991317.

Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030. PMID: 17308304.

Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616. PMID: 16129684.

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Keywords: Pam2CSK4, supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Tocris Bioscience, Toll-like Receptor Agonist products

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