Cat. No. 4635
Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxyca
Biological ActivityActivator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581. PMID: 22689977.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SC 79 include:
Wilson et al (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6 17735. PMID: 26787558.
Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76. PMID: 25889299.
Do you know of a great paper that uses SC 79 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SC 79, supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, Tocris Bioscience, Akt (Protein Kinase B) Activator products
Find multiple products by catalog number
New Products in this Area
Potent Nek2 inhibitorRoscovitine
Potent, selective cyclin-dependent kinase inhibitorEnzastaurin
Potent PKCβ inhibitorBMS 265246
Potent cdk1/2 inhibitorAutocamtide-2-related inhibitory peptide, myristoylated
CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptideMP A08
Selective ATP competitive SphK1 and 2 inhibitor; cell permeableAkti-1/2
Potent and selective dual Akt1 and 2 inhibitorVX 680
High affinity and selective Aurora kinase inhibitorImatinib mesylate
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kitTGX 221
Potent and selective PI 3-kinase β inhibitorPF 543 hydrochloride
Potent and selective SphK1 inhibitorJX 06
Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitorMRT 68601 hydrochloride
Potent TBK1 inhibitorAzoramide
Unfolded protein response (UPR) modulator
November 12 - 16, 2016
San Diego, CA, USA