Cat. No. 4635
Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxyca
Biological ActivityActivator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581. PMID: 22689977.
If you know of a relevant reference for SC 79 please let us know.
Citations are publications that use Tocris products. Selected citations for SC 79 include:
Bei et al (2016) miR-382 targeting PTEN-Akt axis promotes liver regeneration. Mol Syst Biol 7 1584. PMID: 26636539.
Wilson et al (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6 17735. PMID: 26787558.
Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76. PMID: 25889299.
Sladitschek and Neveu (2015) The bimodally expressed microRNA miR-142 gates exit from pluripotency. Sci Rep 11 850. PMID: 26690966.
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Keywords: SC 79, supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, Tocris Bioscience, Akt (Protein Kinase B) Activator products
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