Cat. No. 4633
Biological ActivityToll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088. PMID: 22351935.
St Paul et al (2012) Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616. PMID: 23116495.
Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551. PMID: 1312332.
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Keywords: Pam3CSK4, supplier, toll, like, receptors, TLRs, agonists, ligands, induces, cytokines, production, IFNg, TNFa, TNFalpha, IL-6, interleukin, Tocris Bioscience, Toll-like Receptor Agonist products
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