Pam3CSK4

Cat. No. 4633

Pam3CSK4 Pam3-Cys-Ser-Lys-Lys-Lys-Lys

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Biological Activity

Toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.

Technical Data

M.Wt:
1510.24
Formula:
C81H156N10O13S
Sequence:
CSKKKK

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl]-Cys

Solubility:
Soluble to 1 mg/ml in 50% Ethanol / water
Storage:
Store at -20°C
CAS No:
112208-00-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088. PMID: 22351935.

St Paul et al (2012) Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616. PMID: 23116495.

Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551. PMID: 1312332.

If you know of a relevant reference for Pam3CSK4 please let us know.

Citations are publications that use Tocris products.

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Keywords: Pam3CSK4, supplier, toll, like, receptors, TLRs, agonists, ligands, induces, cytokines, production, IFNg, TNFa, TNFalpha, IL-6, interleukin, Tocris Bioscience, Toll-like Receptor Agonist products

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