Cat. No. 4633
Biological ActivityToll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088. PMID: 22351935.
St Paul et al (2012) Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616. PMID: 23116495.
Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551. PMID: 1312332.
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Keywords: Pam3CSK4, supplier, toll, like, receptors, TLRs, agonists, ligands, induces, cytokines, production, IFNg, TNFa, TNFalpha, IL-6, interleukin, Tocris Bioscience, Toll-like Receptor Agonist products
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