SB 747651A dihydrochloride

Cat. No. 4630

SB 747651A dihydrochloride C16H22N8O.2HCl [1781882-72-1]

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Chemical Name: 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

Biological Activity

Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data

M.Wt:
415.32
Formula:
C16H22N8O.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1781882-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Naqvi et al (2012) Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem.J. 441 347. PMID: 21970321.

Bamford et al (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 15 3402. PMID: 15950465.

Bamford et al (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 15 3407. PMID: 15955699.

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Keywords: SB 747651A dihydrochloride, supplier, SB747651A, mitogen, and, stress, activated, kinase, inhibitors, inhibits, MSK1, MSK2, potent, IL-10, production, cell, permeable, AGC, group, Tocris Bioscience, Other Kinase Inhibitor products

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