Cat. No. 4628
Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[
Biological ActivitySelective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545. PMID: 22235307.
Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345. PMID: 22553215.
Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508. PMID: 21127131.
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Keywords: DiMNF, supplier, DiMNF, aryl, hydrocarbon, receptors, AhRs, modulators, SAhRMs, anti-inflammatories, anti-inflammatory, Tocris Bioscience, Aryl Hydrocarbon Receptor Modulator products
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