Cat. No. 4628

DiMNF C21H16O4 [14756-24-2]

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Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one

Biological Activity

Selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.

Technical Data

Soluble to 5 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545. PMID: 22235307.

Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345. PMID: 22553215.

Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508. PMID: 21127131.

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Keywords: DiMNF, supplier, DiMNF, aryl, hydrocarbon, receptors, AhRs, modulators, SAhRMs, anti-inflammatories, anti-inflammatory, Tocris Bioscience, Aryl Hydrocarbon Receptor Modulator products

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