Cat. No. 4627

Phlorizin C21H24O10 [60-81-1]

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Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Biological Activity

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31. PMID: 15624123.

Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10. PMID: 11133510.

Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J.Clin.Invest. 79 1510. PMID: 3571496.

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Keywords: Phlorizin, supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, Tocris Bioscience, Other Ion Pumps/Transporter Inhibitor products

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