Phlorizin

Cat. No. 4627

Phlorizin C21H24O10 [60-81-1]

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Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Biological Activity

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Technical Data

M.Wt:
436.41
Formula:
C21H24O10
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
60-81-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31. PMID: 15624123.

Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10. PMID: 11133510.

Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J.Clin.Invest. 79 1510. PMID: 3571496.

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Citations are publications that use Tocris products.

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Keywords: Phlorizin, supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, Tocris Bioscience, Other Ion Pumps/Transporter Inhibitor products

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