Cat. No. 4621
Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3
Biological ActivityOccupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Patury et al (2009) Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 9 1337. PMID: 19860737.
Wadhwa et al (2002) Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 62 4434. PMID: 12154051.
Wadhwa et al (2000) Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60 6818. PMID: 11156371 .
Tikoo et al (1999) Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 5 293. PMID: 10526670.
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Keywords: MKT 077, supplier, MKT077, heat, shock, proteins, 70, Hsp70, Hsps, inhibitors, inhibits, telomerase, inhibitors, inhibits, F-actin, cross-linkers, Tocris Bioscience, Hsp70 products
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