Cat. No. 4620
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propy
Biological ActivityProdrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kim et al (1997) Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats. Hypertens.Res. 20 133. PMID: 9220278.
Mizuno et al (1995) Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur.J.Pharmacol. 285 181. PMID: 8566137.
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Keywords: Olmesartan medoxomil, supplier, CS866, antagonists, RNH-6270, AT1, receptors, angiotensin, II, type, I, receptor, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products