Olmesartan medoxomil

Cat. No. 4620

Olmesartan medoxomil C29H30N6O6 [144689-63-4]

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Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylic acid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Biological Activity

Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT1) antagonist. Selectively inhibits angiotensin II binding to AT1 receptors in bovine adrenal cortical membranes (IC50 = 7.7 nM), with no effect on AT2 receptors.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kim et al (1997) Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac gene expression in rats. Hypertens.Res. 20 133. PMID: 9220278.

Mizuno et al (1995) Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur.J.Pharmacol. 285 181. PMID: 8566137.

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Keywords: Olmesartan medoxomil, supplier, CS866, antagonists, RNH-6270, AT1, receptors, angiotensin, II, type, I, receptor, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products

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