Cat. No. 4619

Melphalan C13H18Cl2N2O2 [148-82-3]

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Chemical Name: 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine

Biological Activity

DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in 1eq. HCl
>95 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mougenot et al (2006) In vitro cytotoxic effect of melphalan and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 26 2197. PMID: 16821586.

Bauer and Povirk (1997) Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 25 1211. PMID: 9092631.

Blumberg et al (1965) An alkylating agent for multiple myeloma: melphalan. JAMA. 191 547. PMID: 14239026.

Merck Index 12 5872.

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Keywords: Melphalan, supplier, antineoplastics, alkylating, DNA, agents, chemotherapeutics, cytotoxic, crosslinks, Tocris Bioscience, Other Apoptosis products

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