Cat. No. 4616
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propy
Biological ActivityPotent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil (Cat. No. 4620).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chuang et al (2012) Effects of olmesartan on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66. PMID: 22694778.
Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801. PMID: 21123673.
Mogi et al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan. Neuropharmacology 53 899. PMID: 18028965.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Olmesartan from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Olmesartan, supplier, rnh, 6270, rnh6270, olmetec, benicar, potent, antagonists, angiotensin, II, receptors, blockers, ARBs, AT1, antihypertensive, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective Mas receptor (Ang-(1-7) receptor) antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.