Cat. No. 4615

MEDICA 16 C20H38O4 [87272-20-6]

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Chemical Name: 3,3,14,14-Tetramethylhexadecanedioic acid

Biological Activity

Free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247. PMID: 19471906.

Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats. Diabetes 51 1548. PMID: 11978655.

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Keywords: MEDICA 16, supplier, MEDICA16, free, fatty, acid, receptors, 1, FFA1, FFAR1, GPR40, agonists, ATP, citrate, lyases, inhibitors, inhibits, lipogenesis, insulin, sensitivity, triacylglyerol, synthases, transferases, ACLY, Tocris Bioscience, Free Fatty Acid Receptor Agonist products

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