Cat. No. 4615
Chemical Name: 3,3,14,14-Tetramethylhexadecanedioi
Biological ActivityFree fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247. PMID: 19471906.
Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats. Diabetes 51 1548. PMID: 11978655.
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Keywords: MEDICA 16, supplier, MEDICA16, free, fatty, acid, receptors, 1, FFA1, FFAR1, GPR40, agonists, ATP, citrate, lyases, inhibitors, inhibits, lipogenesis, insulin, sensitivity, triacylglyerol, synthases, transferases, ACLY, Tocris Bioscience, Free Fatty Acid Receptor Agonist products
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