URB 597

Cat. No. 4612

URB 597  [546141-08-6]

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Chemical Name: Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester

Biological Activity

Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Technical Data

M.Wt:
338.4
Formula:
C20H22N2O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
546141-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281. PMID: 16331291.

Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21. PMID: 16834756.

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108. PMID: 15973410.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for URB 597 include:

Morena et al (2016) Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology 111 59. PMID: 27553121.

Vilela et al (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. J Neurosci 2015 523418. PMID: 25999668.

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm 2014 978678. PMID: 24803745.

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320. PMID: 23008234.

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Keywords: URB 597, supplier, URB597, faah, fatty, acid, amide, hydrolase, inhibitors, inhibits, selective, potent, Tocris Bioscience, FAAH Inhibitor products

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