Cat. No. 4607
Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-ben
Biological ActivityPotent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Schmid et al (2012) A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 32 1803. PMID: 22302819.
Massa et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 120 1774. PMID: 20407211.
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Citations are publications that use Tocris products. Selected citations for LM 22A4 include:
Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328. PMID: 24356881.
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Keywords: LM 22A4, supplier, LM22A4, tropomyosin, related, kinases, B, TrkB, agonists, potent, Rett, syndrome, Tocris Bioscience, Trk Receptor Agonist products
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