LM 22A4

Cat. No. 4607

LM 22A4 C15H21N3O6 [37988-18-4]

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Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

Biological Activity

Potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.

Technical Data

M.Wt:
339.34
Formula:
C15H21N3O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
37988-18-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Schmid et al (2012) A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 32 1803. PMID: 22302819.

Massa et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 120 1774. PMID: 20407211.

If you know of a relevant reference for LM 22A4 please let us know.

Citations are publications that use Tocris products. Selected citations for LM 22A4 include:

Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328. PMID: 24356881.

Do you know of a great paper that uses LM 22A4 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: LM 22A4, supplier, LM22A4, tropomyosin, related, kinases, B, TrkB, agonists, potent, Rett, syndrome, Tocris Bioscience, Trk Receptor Agonist products

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