Cat. No. 4605
Chemical Name: 3-(4-Chlorophenyl)-N-[(4-Chlorophen
Biological ActivityPotent and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. Inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lange et al (2005) Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg.Med.Chem.Lett. 15 4794. PMID: 16140010.
Lange et al (2004) Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J.Med.Chem. 47 627. PMID: 14736243.
If you know of a relevant reference for (±)-SLV 319 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses (±)-SLV 319 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: (±)-SLV 319, supplier, (±)-SLV319, SLV, 319, SLV319, potent, selective, CB1, antagonists, cannabinoids, receptors, Tocris Bioscience, CB1 Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent and selective CB2 partial agonist; orally biovailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.