Cat. No. 4604
Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-
Biological ActivityPotent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Son et al (2012) A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213. PMID: 21951056.
Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160. PMID: 17980460.
If you know of a relevant reference for PTIQ please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PTIQ from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PTIQ, supplier, potent, MMP-3, expression, inhibitors, neuroprotective, dopamingeric, dopamine, NO, nitric, oxide, neurodegeneration, Parkinson's, disease, blood, brain, barrier, permeable, MPTP, -, inhibits, PD, brain, penetrant, Tocris Bioscience, Matrix Metalloprotease products
Find multiple products by catalog number
New Products in this Area
Selective high affinity MMP2 inhibitor(R)-MG 132
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.