PTIQ

Cat. No. 4604

PTIQ C13H17NO3 [1032822-42-6]

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Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone

Biological Activity

Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.

Technical Data

M.Wt:
235.28
Formula:
C13H17NO3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
1032822-42-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Son et al (2012) A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213. PMID: 21951056.

Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160. PMID: 17980460.

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Keywords: PTIQ, supplier, potent, MMP-3, expression, inhibitors, neuroprotective, dopamingeric, dopamine, NO, nitric, oxide, neurodegeneration, Parkinson's, disease, blood, brain, barrier, permeable, MPTP, -, inhibits, PD, brain, penetrant, Tocris Bioscience, Matrix Metalloprotease products

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