Cat. No. 4604
Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-
Biological ActivityPotent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Son et al (2012) A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213. PMID: 21951056.
Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160. PMID: 17980460.
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Keywords: PTIQ, supplier, potent, MMP-3, expression, inhibitors, neuroprotective, dopamingeric, dopamine, NO, nitric, oxide, neurodegeneration, Parkinson's, disease, blood, brain, barrier, permeable, MPTP, -, inhibits, PD, brain, penetrant, Tocris Bioscience, Matrix Metalloprotease products
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