Cat. No. 4602
Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylt
Biological ActivityTransglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Prime et al (2012) Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J.Med.Chem. 55 1021. PMID: 22224594.
Case and Stein (2007) Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 46 1106. PMID: 17240993.
Duval et al (2005) Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 15 1885. PMID: 15780627.
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Citations are publications that use Tocris products. Selected citations for LDN 27219 include:
Yeo et al (2016) Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Mediators Inflamm 5. PMID: 26956429.
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Keywords: LDN 27219, supplier, LDN27219, transglutaminases, 2, TG2, TGase, tissue, tTG, inhibits, inhibitors, reversible, Tocris Bioscience, Other Transferase Inhibitor products
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