Cat. No. 4602
Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylt
Biological ActivityTransglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Prime et al (2012) Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J.Med.Chem. 55 1021. PMID: 22224594.
Case and Stein (2007) Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 46 1106. PMID: 17240993.
Duval et al (2005) Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 15 1885. PMID: 15780627.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for LDN 27219 include:
Yeo et al (2016) Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Mediators Inflamm 5. PMID: 26956429.
Do you know of a great paper that uses LDN 27219 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LDN 27219, supplier, LDN27219, transglutaminases, 2, TG2, TGase, tissue, tTG, inhibits, inhibitors, reversible, Tocris Bioscience, Other Transferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent cholesteryl ester transfer protein (CETP) inhibitorPerhexiline maleate
Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitorMS 023 dihydrochloride
Potent and selective type I PRMT inhibitor
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AACR 2017.