TUG 891

Cat. No. 4601

TUG 891 C23H21FO3 [1374516-07-0]

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Chemical Name: 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid

Biological Activity

Potent FFA4 (GPR120) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Licensing Information

Sold under license from the University of Southern Denmark.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Shimpukade et al (2012) Discovery of a potent and selective GPR120 agonist. J.Med.Chem. 55 4511. PMID: 22519963.

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Keywords: TUG 891, supplier, TUG891, GPR120, agonists, potent, selective, FFA1, FFA2, FFA3, cell, permeable, FFA4, free, fatty, acid, receptors, Tocris Bioscience, Free Fatty Acid Receptor Agonist products

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