Auranofin

Cat. No. 4600

Auranofin C20H34AuO9PS [34031-32-8]

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Chemical Name: 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate

Biological Activity

Inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.

Technical Data

M.Wt:
678.48
Formula:
C20H34AuO9PS
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Storage:
Store at RT
CAS No:
34031-32-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kim et al (2007) Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 122 607. PMID: 17645497.

Rigobello et al (2002) Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br.J.Pharmacol. 136 1162. PMID: 12163349.

Gromer et al (1998) Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J.Biol.Chem. 273 20096. PMID: 9685351.

Betts et al (1990) Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils. Biochem.Pharmacol. 39 1233. PMID: 2157444.

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