Cat. No. 4600
Chemical Name: 1-Thio-β-D-glucopyranosatotriethylph
Biological ActivityInhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kim et al (2007) Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 122 607. PMID: 17645497.
Rigobello et al (2002) Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br.J.Pharmacol. 136 1162. PMID: 12163349.
Gromer et al (1998) Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J.Biol.Chem. 273 20096. PMID: 9685351.
Betts et al (1990) Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils. Biochem.Pharmacol. 39 1233. PMID: 2157444.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Auranofin from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Auranofin, supplier, antirheumatic, antiarthritic, arthritis, mitochondrial, permeability, pore, transition, mpt, inducers, anti-inflammatory, anti-inflammatories, immunosuppressive, immunosuppressants, thioredoxin, reductase, TrxR, inhibitors, inhibits, Tocris Bioscience, Other Reductase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Protein disulfide isomerase (PDI) inhibitor3-AP
Ribonucleotide reductase inhibitor; also an iron chelator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.