Cat. No. 4599
Chemical Name: 3,5-Dihydroxybenzoic acid
Biological ActivitySelective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Liu et al (2012) 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 341 794. PMID: 22434674.
If you know of a relevant reference for 3,5-DHBA please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses 3,5-DHBA from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 3,5-DHBA, supplier, gpr81, orphan, receptors, hca1, hydroxycarboxylic, acid, receptor, 1, hca1, selective, agonists, Tocris Bioscience, Hydroxycarboxylic Acid Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppresantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonistZQ 16
Selective GPR84 agonistIHR-Cy3
Potent fluorescent Smo antagonistRo 6842262
Potent LPA1 antagonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.