Cat. No. 4596
Chemical Name: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,
Biological ActivityPotent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Thoma et al (2008) Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 51 7915. PMID: 19053768.
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Keywords: IT1t dihydrochloride, supplier, CXCR4, antagonists, HIV, envelope, protein, gp120, chemokines, receptors, type, 4, Tocris Bioscience, Chemokine CXC Receptor Antagonist products