Cat. No. 4592
Biological ActivityCell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Morishita et al (2011) Cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. J.Biol.Chem. 286 2681. PMID: 21062737.
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Keywords: R8-T198wt, supplier, anticancer, prostate, cancer, Pim-1, kinases, inhibits, inhibitors, DU145, cells, cell, lines, p27Kip1, Tocris Bioscience, Pim Kinase Inhibitor products
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