Cat. No. 4591
Biological ActivityPotent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.
(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fiori et al (1997) Deltorphin transport across the blood-brain barrier. Proc.Natl.Acad.Sci.USA 94 9469. PMID: 9256506.
Stefano et al (1992) [D-Ala2]Deltorphin I binding and pharmacological evidence for a special subtype of δ opioid receptor on human and invertebrate immune cells. Proc.Natl.Acad.Sci.USA 89 9316. PMID: 1329092.
Erspamer et al (1989) Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc.Natl.Acad.Sci.USA 86 5188. PMID: 2544892.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Deltorphin I include:
Otis et al (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183 221. PMID: 21458544.
Do you know of a great paper that uses Deltorphin I from Tocris? If so please let us know.
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Keywords: Deltorphin I, supplier, DeltorphinI, delta, d, δ, opioids, agonists, brain, penetrant, bbb, Tocris Bioscience, δ Opioid Receptor Agonist products
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