Honokiol

Cat. No. 4590

Honokiol C18H18O2 [35354-74-6]

Price and Availability

For Honokiol pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl

Biological Activity

Anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

Technical Data

M.Wt:
266.33
Formula:
C18H18O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
35354-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pillai et al (2015) Nat.Commun. 6 6656. PMID: 25871545.

Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589. PMID: 18640101.

Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113. PMID: 18158873.

Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621. PMID: 16966432.

Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501. PMID: 12816951.

If you know of a relevant reference for Honokiol please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Honokiol from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Honokiol, supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, Tocris Bioscience, NF-κB and IκB Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Asthma Life Science Poster

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

NF-κB Signaling Pathway

NF-κB Signaling Pathway

Signals through the NF-κB pathway are important in the inflammation and the adaptive and innate immune response. View pathway or download PDF today.

divider line

New Products in this Area

RAGE antagonist peptide

Receptor for advanced glycation end products (RAGE) antagonist

Galiellalactone

STAT3 inhibitor; active in vivo

CP 424174

Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3

IT 901

NF-κB c-Rel subunit inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.