Cat. No. 4590
Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Biological ActivityAnti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pillai et al (2015) Nat.Commun. 6 6656. PMID: 25871545.
Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589. PMID: 18640101.
Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113. PMID: 18158873.
Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621. PMID: 16966432.
Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501. PMID: 12816951.
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Keywords: Honokiol, supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, Tocris Bioscience, NF-κB and IκB Inhibitor products
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