8MDP

Cat. No. 4588

8MDP C28H48N8O4 [29491-75-6]

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Chemical Name: 2,2',2'',2'''-[[4,8-Bis(hexahydro-1(2H)-azocinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol

Biological Activity

Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively.

Technical Data

M.Wt:
560.73
Formula:
C28H48N8O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
29491-75-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe. Bioconjug.Chem. 22 1221. PMID: 21539390.

Lin et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906. PMID: 17636949.

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Keywords: 8MDP, supplier, ENT1, inhibitors, inhibits, potent, equilibrative, nucleoside, transporters, 1, 2, ENT2, transports, Tocris Bioscience, Nucleoside Transporter Inhibitor products

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