MRT 10

Cat. No. 4585

MRT 10 C24H23N3O5S [330829-30-6]

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Chemical Name: N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide

Biological Activity

Smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells).

Technical Data

M.Wt:
465.52
Formula:
C24H23N3O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
330829-30-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559. PMID: 22268551.

Manetti et al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658. PMID: 20664000.

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Keywords: MRT 10, supplier, MRT10, smoothened, receptor, antagonists, inhibitors, inhibits, hedgehog, pathway, inverse, agonists, nontranscriptional, Gli, Shh, sonic, Tocris Bioscience, Smoothened Receptor Antagonist products

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