Cat. No. 4585
Chemical Name: N-[[[3-Benzoylamino)phenyl]amino]th
Biological ActivitySmoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559. PMID: 22268551.
Manetti et al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658. PMID: 20664000.
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Keywords: MRT 10, supplier, MRT10, smoothened, receptor, antagonists, inhibitors, inhibits, hedgehog, pathway, inverse, agonists, nontranscriptional, Gli, Shh, sonic, Tocris Bioscience, Smoothened Receptor Antagonist products
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