Atiprimod dihydrochloride

Cat. No. 4580

Atiprimod dihydrochloride C22H44N2.2HCl [130065-61-1]

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Chemical Name: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride

Biological Activity

JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Technical Data

M.Wt:
409.52
Formula:
C22H44N2.2HCl
Solubility:
Soluble to 50 mM in water and to 10 mM in DMSO with gentle warming
Storage:
Desiccate at RT
CAS No:
130065-61-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831. PMID: 21512135.

Quintás-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818. PMID: 20372971.

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Citations are publications that use Tocris products.

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Keywords: Atiprimod dihydrochloride, supplier, JAK2, kinases, inhibitors, inhibits, induces, apoptosis, proapoptotic, janus, activated, STAT3, STAT5, Tocris Bioscience, JAK Kinase Inhibitor products

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