Cat. No. 4577

LDV FITC N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-Leu-Asp-Val-Pro-Ala-Ala-Lys-FITC

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Biological Activity

Fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes.

Technical Data

LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)
Soluble to 1 mg/ml in PBS (pH 7.4)
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507. PMID: 19754304.

Chigaev et al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951. PMID: 14645084.

Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670. PMID: 11641394.

If you know of a relevant reference for LDV FITC please let us know.

Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: LDV FITC, supplier, LDVFITC, VLA-4, very, late, antigen, VLA4, integrins, alpha4beta1, a4b1, α4, β1, fluorescent, ligands, Tocris Bioscience, Fluorescent Probe products

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