Cat. No. 4575

TC HSD 21 C17H12BrNO3S2 [330203-01-5]

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Chemical Name: 5-[(3-Bromo-4-hydroxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone

Biological Activity

Potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Displays no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Harada et al (2012) Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg.Med.Chem.Lett. 22 504. PMID: 22137341.

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Keywords: TC HSD 21, supplier, TCHSD21, 17beta, HSD3, 17b, 17β, hydroxysteroid, type, 3, potent, selective, inhibitors, inhibits, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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