ARN 272

Cat. No. 4574

ARN 272 C27H20N4O2 [488793-85-7]

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Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide

Biological Activity

FAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.

Technical Data

M.Wt:
432.47
Formula:
C27H20N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
488793-85-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Piscitelli and Marzo (2012) "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem.Neurosci. 3 356. PMID: 22860203.

Fu et al (2011) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat.Neurosci. 15 64. PMID: 22101642.

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Keywords: ARN 272, supplier, ARN272, FAAH, like, anandamide, transporters, FLAT, inhibitors, inhibits, cytosolic, variant, FAAH1, nociceptive, inflammatory, pain, analgesics, Tocris Bioscience, Fatty Acid Amide Hydrolase Inhibitor products

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