Cat. No. 4574
Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazi
Biological ActivityFAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Piscitelli and Marzo (2012) "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem.Neurosci. 3 356. PMID: 22860203.
Fu et al (2011) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat.Neurosci. 15 64. PMID: 22101642.
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Keywords: ARN 272, supplier, ARN272, FAAH, like, anandamide, transporters, FLAT, inhibitors, inhibits, cytosolic, variant, FAAH1, nociceptive, inflammatory, pain, analgesics, Tocris Bioscience, Fatty Acid Amide Hydrolase Inhibitor products