Cat. No. 4574
Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazi
Biological ActivityFAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Piscitelli and Marzo (2012) "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem.Neurosci. 3 356. PMID: 22860203.
Fu et al (2011) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat.Neurosci. 15 64. PMID: 22101642.
If you know of a relevant reference for ARN 272 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ARN 272 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ARN 272, supplier, ARN272, FAAH, like, anandamide, transporters, FLAT, inhibitors, inhibits, cytosolic, variant, FAAH1, nociceptive, inflammatory, pain, analgesics, Tocris Bioscience, Fatty Acid Amide Hydrolase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent DDHD2 inhibitorPDD 00017273
Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable
July 8 - 12, 2017