Cat. No. 4571
Chemical Name: 4-[5-(4-Chlorophenyl)-2-methyl-3-(1
Biological ActivityPositive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Faghih et al (2009) Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 28 3377. PMID: 19419141.
Malysz et al (2009) In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. J.Pharmacol.Exp.Ther. 330 257. PMID: 19389923.
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Keywords: A 867744, supplier, A867744, positive, allosteric, modulators, a7, alpha7, acetylcholine, nicotinic, receptors, nAChRs, selective, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products
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