Cat. No. 4570
Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phe
Biological ActivityInhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232. PMID: 22408714.
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Keywords: ML 161, supplier, ML161, inhibitors, inhibits, protease-activated, proteinase-activated, receptors, par1, Tocris Bioscience, Protease-Activated Receptor products
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