ML 161

Cat. No. 4570

ML 161 C17H17BrN2O2 [423735-93-7]

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Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide

Biological Activity

Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.

Technical Data

M.Wt:
361.23
Formula:
C17H17BrN2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
423735-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232. PMID: 22408714.

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Keywords: ML 161, supplier, ML161, inhibitors, inhibits, protease-activated, proteinase-activated, receptors, par1, Tocris Bioscience, Protease-Activated Receptor products

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