CPYPP

Cat. No. 4568

CPYPP  [310460-39-0]

Price and Availability

For CPYPP pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione

Biological Activity

DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.

Technical Data

M.Wt:
324.76
Formula:
C18H13ClN2O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
310460-39-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Laurin et al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434. PMID: 23592719.

Nishikimi et al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488. PMID: 22520755.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CPYPP from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CPYPP, supplier, DOCK2, DOCK1, DOCK180, DOCK5, Rac1, interaction, inhibitors, inhibits, Tocris Bioscience, G Protein (Small) products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

WL 47 - dimer

High affinity caveolin-1 ligand

SAG 21k

Hedgehog signaling activator; brain penetrant and orally bioavailable

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.