CCG 50014

Cat. No. 4567

CCG 50014 C16H13FN2O2S [883050-24-6]

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Chemical Name: 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione

Biological Activity

Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Vashisth et al (2013) Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem.Biol. 8 2778. PMID: 24093330.

Turner et al (2012) Small molecule inhibitors of regulators of G protein signalling (RGS) proteins. ACS Med.Chem.Lett. 3 146. PMID: 22368763.

Blazer et al (2011) A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50 3181. PMID: 21329361.

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Keywords: CCG 50014, supplier, CCG50014, potent, selective, RGS4, inhibitors, inhibits, regulator, G-protein, signaling, signalling, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products

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