Cat. No. 4566
Alternative Name: b-AP15
Chemical Name: 3,5-Bis[(4-nitrophenyl)methylene]-1
Biological ActivityInhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
D'Arcy et al (2011) Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat.Med. 17 1636. PMID: 22057347.
Berndtsson et al (2009) Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int.J.Cancer 124 1463. PMID: 19089926.
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Keywords: NSC 687852, supplier, NSC687852, 19S, regulatory, particle, associated, deubiquitylating, enzymes, DUBs, apoptosis, UCHL5, USP14, cathepsin, D, dependent, caspase, cleavage, antitumor, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products
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