NSC 687852

Cat. No. 4566

NSC 687852 C22H17N3O6 [1009817-63-3]

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Alternative Name: b-AP15

Chemical Name: 3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone

Biological Activity

Inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo.

Technical Data

M.Wt:
419.39
Formula:
C22H17N3O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
1009817-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

D'Arcy et al (2011) Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat.Med. 17 1636. PMID: 22057347.

Berndtsson et al (2009) Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int.J.Cancer 124 1463. PMID: 19089926.

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Keywords: NSC 687852, supplier, NSC687852, 19S, regulatory, particle, associated, deubiquitylating, enzymes, DUBs, apoptosis, UCHL5, USP14, cathepsin, D, dependent, caspase, cleavage, antitumor, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

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