GTS 21 dihydrochloride
Cat. No. 4557
Alternative Name: DMXBA
Chemical Name: 3-[(2,4-Dimethoxyphenyl)methylene]-
Biological ActivityPartial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Olincy et al (2012) Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb.Exp.Pharmacol. 213 211. PMID: 23027417.
Stevens et al (2010) Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain.Res. 1352 140. PMID: 20599427.
Meyer et al (1994) Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev.Res. 31 127.
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