Cat. No. 4553
Chemical Name: 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1
Biological ActivityPotent angiotensin II type 1 (AT1) receptor inverse agonist (IC50 = 2.6 nM at the human AT1 receptor). Inhibits angiotensin II-induced IP1 accumulation in COS-7 cells; decreases maximal contraction of rabbit aortic strips in a concentration-dependent manner (pD'2 = 9.9). Antihypertensive; prevents vascular cell proliferation and expression of PAI-1.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
French et al (2011) The angiotensin receptor blocker, azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I protein potentially facilitating the stabilization of atherosclerotic plaques. J.Cardiovasc.Pharmacol. 58 143. PMID: 21558880.
Kajiya et al (2011) Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J.Hypertens. 29 2476. PMID: 21986624.
Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801. PMID: 21123673.
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Keywords: Azilsartan, supplier, angiotensin, II, receptor, inverse, agonist, inhibits, inhibitors, antihypertensive, antiproliferative, PAI-1, expression, plasminogen, activator, inhibitor, 1, potent, selective, slow, dissociating, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products