A 412997 dihydrochloride

Cat. No. 4552

A 412997 dihydrochloride C19H23N3O.2HCl [1347744-96-0]

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Chemical Name: N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide

Biological Activity

Selective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Technical Data

M.Wt:
382.33
Formula:
C19H23N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1347744-96-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Patel et al (2006) Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J.Med.Chem. 49 7450. PMID: 17149874.

Browman et al (2005) A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 82 148. PMID: 16154186.

Moreland et al (2005) A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol.Biochem.Behav. 82 140. PMID: 16153699.

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Keywords: A 412997 dihydrochloride, supplier, A412997, selective, agonists, dopamine, dopaminergic, d4, Tocris Bioscience, D4 Receptor Agonist products

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