IQ 3

Cat. No. 4550

IQ 3  [312538-03-7]

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Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime

Biological Activity

Selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.

Technical Data

M.Wt:
341.32
Formula:
C20H11N3O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
312538-03-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832. PMID: 22434859.

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Citations are publications that use Tocris products. Selected citations for IQ 3 include:

Easton et al (2014) Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J Neurosci 34 3854. PMID: 24623764.

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Keywords: IQ 3, supplier, IQ3, Selective, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, IQ3, JNK/c-jun, c-jun, MAPK, kinases, Tocris Bioscience, JNK/c-Jun Inhibitor products

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