ML 133 hydrochloride
Cat. No. 4549
Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-napht
Biological ActivitySelective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wang et al (2011) Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 6 845. PMID: 21615117.
Wu et al (2010) A potent and selective small molecule Kir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro. PMID: 21433384.
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Citations are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:
Lam and Schlichter (2015) Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Nat Commun 9 185. PMID: 26029054.
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