Cat. No. 4547

ACHP C21H24N4O2 [406208-42-2]

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Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile

Biological Activity

IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.

Technical Data

Soluble to 20 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Sanda et al (2005) Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor. Clin.Cancer Res. 11 1974. PMID: 15756023.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ACHP include:

Mbongue et al (2015) Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine. Front Cell Neurosci 10 e0118562. PMID: 25714914.

Mia and Bank (2015) The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis. J Cell Mol Med. PMID: 26337045.

Do you know of a great paper that uses ACHP from Tocris? If so please let us know.

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Keywords: ACHP, supplier, IkappaB, IKB, kinase, IKKalpha, IKKa, IKKbeta, IKKb, inhibitors, inhibits, NF-kB, pathway, apoptosis, inducers, cell, growth, arrest, anticancer, Tocris Bioscience, IκB Kinase Inhibitor products

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