Cat. No. 4546
Chemical Name: 4-[2-Amino-5-[4-[(dimethylamino)met
Biological ActivityPotent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228. PMID: 22404346 .
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Keywords: rac-CCT 250863, supplier, rac-CCT250863, potent, NEK2, inhibitors, inhibits, selective, never-in-mitosis-gene-a-related, kinases, Tocris Bioscience, Other Kinase Inhibitor products
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