rac-CCT 250863

Cat. No. 4546

rac-CCT 250863 C24H25F3N4O2S [1364269-06-6]

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Chemical Name: 4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide

Biological Activity

Potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.

Technical Data

M.Wt:
490.54
Formula:
C24H25F3N4O2S
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1364269-06-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228. PMID: 22404346 .

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Keywords: rac-CCT 250863, supplier, rac-CCT250863, potent, NEK2, inhibitors, inhibits, selective, never-in-mitosis-gene-a-related, kinases, Tocris Bioscience, Other Kinase Inhibitor products

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