Cat. No. 4543
Chemical Name: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-
Biological ActivitySphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nakamura et al (2012) Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Eur.J.Med.Chem. 51 92. PMID: 22405291.
Nakamura et al (2012) Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg.Med.Chem.Lett. 22 1788. PMID: 22264485.
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Keywords: CS 2100, supplier, CS2100, sphingosine-1-phosphate, receptors, S1P1, selective, agonists, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products
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