Cat. No. 4540
Chemical Name: 4-[[[(4-Fluorophenyl)amino]carbonyl
Biological ActivityPotent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lou et al (2011) Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71 3364. PMID: 21415165.
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Keywords: U 104, supplier, U104, supplier, potent, carbonic, anhydrase, XI, XII, 9, 12, CA, inhibitors, inhibits, metastatic, metastasis, hypoxic, hypoxia, Tocris Bioscience, Carbonic Anhydrase Inhibitor products
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December 13 - 15, 2016