T16Ainh - A01

Cat. No. 4538

T16Ainh - A01 C19H20N4O3S2 [552309-42-9]

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Chemical Name: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

Biological Activity

Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.

Technical Data

M.Wt:
416.52
Formula:
C19H20N4O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
552309-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Duvvuri et al (2012) TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. [Epub ahead of print]. PMID: 22564524.

Mroz and Keely (2012) Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells. J.Physiol. 590 1907. PMID: 22351639.

Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365. PMID: 21084298.

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Citations are publications that use Tocris products. Selected citations for T16Ainh - A01 include:

Pineda-Farias et al (2015) Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Cell Death Dis 11 41. PMID: 26130088.

Zhang et al (2015) Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. PLoS One 10 e0142160. PMID: 26558388.

Zhang et al (2015) TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients. Mol Pain 7 367. PMID: 25749771.

Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. PLoS One 4 e969. PMID: 24357800.

Jeon et al (2013) Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS One 8 e67989. PMID: 23840801.

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Keywords: T16Ainh - A01, supplier, T16Ainh-A01, supplier, ca2+, calcium, activated, sensitive, chloride, Cl-, channels, CaCC, transmembrane, TMEM16A, inhibitors, inhibits, antiproliferative, antitumor, Tocris Bioscience, Calcium-activated Chloride Channel Blocker products

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