Cat. No. 4537
Chemical Name: (αS)-6-Methoxy-α-methyl-2-naphthalene
Biological ActivityCyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Pini et al (2012) Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor. J.Pharmacol.Exp.Ther. 341 493. PMID: 22344408.
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Keywords: NCX 466, supplier, NCX466, Cyclooxygenases, COX, COX1, COX2, COX-1, COX-2, inhibitors, inhibits, nitric, oxide, NO, donor, CINOD, inflammation, anti-inflammatory, profibrotic, Tocris Bioscience, Cyclooxygenase Inhibitor products
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April 1 - 5, 2017
Washington, D.C., USA