Cat. No. 4536
Alternative Name: R 848
Chemical Name: 1-[4-Amino-2-(ethoxymethyl)-1H-imid
Biological ActivityToll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lee et al (2014) Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 37 1234. PMID: 24748512.
Miyamoto et al (2012) R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 64 331. PMID: 22358541.
Dockrell and Kinghorn (2001) Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 48 751. PMID: 11733457.
Wagner et al (1999) Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol. 191 10. PMID: 9918682.
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Keywords: Resiquimod, supplier, proinflammatory, toll, like, receptors, ligands, agonists, TLR7, cytokines, interferons, interleukins, R848, R_848, myeloid-derived, suppressor, cells, MDSCs, tumor, microenvironment, Tocris Bioscience, Toll-like Receptor Agonist products
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