Phalloidin

Cat. No. 4535

Phalloidin Ala-D-Thr-Cys-Hyp-Ala-Trp-Leu (Modifications: Cyclic Cys-3-Trp-6)

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Biological Activity

Promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.

Technical Data

M.Wt:
788.87
Formula:
C35H48N8O11S
Sequence:
ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
17466-45-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Diensthuber et al (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. FEBS Lett. 585 767. PMID: 21295570.

Cooper (1987) Effects of cytochalasin and phalloidin on actin. J.Cell Biol. 105 1473. PMID: 3312229.

Coluccio and Tilney (1984) Phalloidin enhances actin assembly by preventing monomer dissociation. J.Cell Biol. 99 529. PMID: 6746738.

Wehland et al (1977) Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc.Natl.Acad.Sci.USA 74 5613. PMID: 341163.

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Keywords: Phalloidin, supplier, actin, polymerization, polymerisation, promoters, Tocris Bioscience, Actin products

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